Digital Genetic Circuits (Microbes as Machines)

[[Media:Spring2015_Digital_Genetic_Circuits_Pre-Discussion_Questions.pdf|Download Pre-Discussion Questions (PDF)]]
These gates are perhaps the farthest away from any natural counterpart and are thus likely to occupy synthetic and systems biologists in the years to come Benenson2013.

= Required Reading/Viewing = // Describes using recombinases to implement digital logic in bacteria. // Accompanying perspective article. // Movie in which Drew Endy explains these "transcriptors".
 * 1) Bonnet2013 pmid=23539178
 * 1) Benenson2013 pmid=23641100
 * 1) Endy2013 Transcriptors & Boolean Integrase Logic (BIL) gates, explained (YouTube)

= Assigned Papers =

// Scalable system for recording "cellular memories" in a genome. // Scalable construction of complex genetic circuits with wide dynamic ranges.
 * 1) Farzadfard2015 pmid=25395541
 * 1) Green2014 pmid=25417166