Analog Genetic Circuits (Microbes as Machines)

[[Media:Spring2015_Analog_Genetic_Circuits_Pre-Discussion_Questions.pdf|Download Pre-Discussion Questions (PDF)]]
Such 'rational network design' may lead both to the engineering of new cellular behaviours and to an improved understanding of naturally occurring networks Elowitz2000.

= Required Reading/Viewing =

// Describes the artificial "repressilator" circuit. Also, view the movie of it in action. // Describes an artificial "toggle switch" circuit.
 * 1) Elowitz2000 pmid=10659856
 * 1) Gardner2000 pmid=10659857
 * 1) Anderson2014 Explanation of the toggle switch and repressilator by J. Chris Anderson (YouTube)

= Assigned Papers =

// Bacteria that can count to three. // Synchronization and modulation of oscillations across multiple cell populations.
 * 1) Friedland2009 pmid=19478183
 * 1) Prindle2012 pmid=22178928

= Additional Resources =

// Movie shows how to create and model the repressilator in TinkerCell
 * 1) Chandran2011 Repressilator in TinkerCell (YouTube)