Expanding the Genetic Code (Microbes as Machines)

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The genetic code was thought to be immutable...Recent developments demonstrate not only that the genetic code can evolve but also that rewiring translation to genetically encode more (possibly many more) than 20 amino acids, primarily by recoding UAG, is both feasible and desirable. ODonoghue2013

= Required Reading/Viewing =

// Overview of topic
 * 1) ODonoghue2013 pmid=24045798

= Assigned Papers =

// Exhaustive review of the topic. Concentrate on methods for the directed evolution of new aminoacyl-tRNA synthetases. // Orthogonal translation systems that utilize a quadruplet codon // Fixing protein release factors for more efficient decoding of UAG // Creating a completely blank codon with "amberless" E. coli
 * 1) Liu2010 pmid=20307192
 * 1) Neumann2010 pmid=20154731
 * 1) Johnson2011 pmid=21926996
 * 1) Lajoie2013 pmid=24136966