Human Genome Editing (Microbes as Machines)

Cyranoski2015 Zimmer2015

[[Media:Spring2015_Human_Genome_Editing_Pre-Discussion_Questions.pdf|Download Pre-Discussion Questions (PDF)]]
"Genome engineering by RNA-programmable Cas9 promises to have broad applications in synthetic biology, direct and multiplexed perturbation of gene networks, and targeted ex vivo and in vivo gene therapy" Charpentier2013.

= Required Reading/Viewing =


 * 1) Cyranoski2015 Cyranoski D and Reardon S. Apr 22 2015. Chinese scientists genetically modify human embryos Nature News
 * 2) Zimmer2015 Zimmer C. Apr 22 2015. Editing Human Embryos: So This Happened National Geographic Blogs: The Loom

= Assigned Papers =

// These two short ones go together. The second is more technical.
 * 1) Charpentier2013 pmid=23467164
 * 2) Mali2014 pmid=23287722
 * 1) Liang2015 pmid=25894090
 * 2) Lanphier2015 pmid=25810189
 * 3) Baltimore2015 pmid=25791083

= Additional Resources =


 * 1) Science Science Special Collection: The CRISPR Revolution